- Add 2 ml of sterile water to the 20 mg vial.
- Do not shake — let it dissolve by itself.
- This makes the solution 10 mg per ml.
Retatrutide 20MG | LY3437943
R1,900.00
RESEARCH PURPOSES ONLY
Retatrutide is an investigational peptide therapy that simultaneously agonises three receptors: GLP-1, GIP, and glucagon. This “triple agonist” action gives it a multi-pronged effect on appetite, metabolism, fat loss, and metabolic health. Read more in the description box below.
INCLUDED IN YOUR ORDER
- 1 x 20mg Vial of Retatrutide
- 5 x 1ml Disposable Insulin syringes with needles
- 1 x Bacteriostatic Water Vial
You will receive your peptide in powdered form.
- Mixing Retatrutide
- Dosage & Titration
- Storing Retatrutide
- Description
- Additional information
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Suggested Weekly Dosage Schedule*
- Weeks 1–4: 2 mg (0.20 ml) once a week. Tolerance phase, not full treatment yet.
- Weeks 5–8: 4 mg (0.40 ml) once a week.
- Weeks 9–12: 8 mg (0.80 ml) once a week.
- Weeks 13–16: 12 mg (1.20 ml) once a week.
This is an investigational GLP-1/GIP/GCGR triple agonist. Like semaglutide or tirzepatide, it is a peptide injection and needs refrigeration (typically stored at 2–8 °C/36–46 °F).
- Always store reconstituted vials refrigerated. (Not in the freezer);
- Store between 2–8 °C/36–46 °F;
- This is a synthetic peptide. Peptides are unstable at room temperature. It should be refrigerated once reconstituted (mixed with bacteriostatic water) and ideally even when in powder form. Some sources recommend freezing the lyophilized powder for long-term storage (up to 24 months).
Discover the benefits of Retatrutide for weight loss in South Africa.
Key Weight-Loss Effects
Retatrutide is one of the newest and most powerful multi-agonist peptides currently being studied for its impressive effects on body fat reduction and overall metabolic health.
- In clinical trials, participants without type 2 diabetes experienced up to 24.2% body weight loss after 48 weeks on the highest dose.
- At 24 weeks, average reductions ranged from 7–18%, depending on dosage and individual response.
- Among participants with type 2 diabetes, Retatrutide resulted in 16–17% average weight loss, alongside significant improvements in blood sugar regulation.
These findings make Retatrutide a next-generation weight management peptide, showing even greater potential than current single or dual-agonist medications.
Additional Benefits / Metabolic Improvements
- Better glycemic control: HbA1c reductions of 1.3–2.0%, demonstrating strong improvements in blood sugar balance.
- Enhanced insulin sensitivity, helping the body utilize glucose more effectively.
- Improved cholesterol and triglyceride levels, contributing to better heart and vascular health.
- Reduced liver fat, which may support individuals with fatty liver disease or metabolic-related steatosis.
- Lower inflammation markers and blood pressure, promoting overall metabolic stability and longevity.
Mechanisms / How It Works
Retatrutide is a triple-agonist peptide, meaning it acts on GLP-1, GIP, and glucagon receptors simultaneously. This triple mechanism gives it a unique and powerful effect:
- GLP-1 activation: Slows gastric emptying, reduces appetite, and helps control blood sugar.
- GIP activation: Boosts insulin sensitivity and amplifies GLP-1 effects for greater fat loss efficiency.
- Glucagon activation: Increases fat oxidation and energy expenditure, helping the body burn stored fat more effectively.
Together, these actions combine to produce enhanced fat loss, reduced food intake, and increased calorie burn, leading to more substantial weight reduction compared to other peptide-based options.
Caveats and Safety
- Retatrutide is for research purposes only and is not currently approved for clinical use.
- The most common side effects reported are nausea, diarrhea, or mild gastrointestinal discomfort, which are typically dose-dependent and improve with gradual dose adjustments.
- Always handle and store this peptide properly, and consult with a qualified professional before conducting any research use.
- Ongoing studies continue to evaluate its long-term safety, metabolic effects, and clinical applications.
Tips for Proper Use and Handling
- Use sterile technique when preparing or administering Retatrutide.
- Rotate injection sites (abdomen, thigh, or arm) to prevent local irritation.
- Start with a low research dose and increase gradually as tolerated.
- Store in a cool, dry environment, away from direct sunlight.
- Pair research protocols with healthy lifestyle habits for optimal metabolic outcomes.
| Dimensions | 40 × 28 × 8 cm |
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